新型药物释放材料褐藻酸盐纤维的制备研究  

Preparation of alginate fiber as a new drug-releasing material

作　　者：张春雪[1] 王苹[2] 袁晓燕[1] 盛京[1] 

机构地区：[1]天津大学材料科学与工程学院,天津300072 [2]天津理工学院生物与化学工程学院,天津300191

出　　处：《天津理工学院学报》2004年第1期82-84,共3页Journal of Tianjin Institute of Technology

摘　　要：利用湿法纺丝钙离子交联的方法制备褐藻酸盐纤维,并将牛血清清蛋白包埋入纤维中,研究了制备条件对纤维性能的影响.用扫描电镜观察纤维的微观形貌;并测试了纤维的力学性能、溶胀性能;测定了蛋白质的包埋效率,以及蛋白质的释放速率.结果表明,湿法纺丝凝固浴的CaCl2浓度影响纤维的力学性能、溶胀性能及蛋白质的释放.Alginate fiber as a novel drug releasing material was prepared by the treating of sodium alginate with calcium chloride. Bovine serum albumin (BSA), a polypeptide modeling drug, was embedded within fibers. Morphology of the fibers was seen by means of scanning electron microscope (SEM). The swelling property and related mechanism of the fibers were determined, and the loading efficiency and accumulated releasing dynamics of BSA proteins were evaluated. Results showed the concentration of CaCl_2 plays an important role in fiber swelling, mechanic property and protein releasing .

关 键 词：药物释放材料 褐藻酸盐纤维 制备 湿法纺丝 包埋效率 释放速率 

分 类 号：R318.08[医药卫生—生物医学工程]