葛根素对糖尿病伴血管病变患者血浆内皮素、一氧化氮含量的影响  

Effects of Puerarin on Plasma Endothelin and Nitric Oxide in Diabetic Patients with Microvascular Complications

作　　者：黄烈虎 叶荣[1] 林晰敏 

机构地区：[1]广东省廉江市人民医院内分泌科,廉江524000

出　　处：《实用中西医结合临床》2004年第2期1-2,共2页Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:探讨葛根素对糖尿病微血管病患者血浆内皮素、一氧化氮含量影响,为临床糖尿病的血管并发症防治寻找理想方法。方法:46例糖尿病伴血管病变患者分为治疗组和对照组,2组基础治疗相同,包括使用口服降糖药或/和胰岛素。治疗组在此基础上加用葛根素0.4g加入生理盐水250mL中静滴,1d 1次,15d为1个疗程,连用3个疗程。治疗前后分别测定血浆ET、NO水平。结果:治疗后,葛根素组ET下降,NO升高显著(P <0.01);与对照组相比,葛根素组治疗后ET、NO改变有显著性差异(P <0.01)。结论::葛根素具有显著调节糖尿病伴血管病变患者血浆ET、NO水平作用,对血管内皮有保护作用。Objective: To evaluate the effects of puerarin on plasma endothelin and nitric oxide in diabetic patients with microvascular complications. Methods: Base treatments of all 46 cases were same, but the treatment of puerarin group was set up as follows: 400mg puerarin in 250mL 5% GNS, ivgtt, qd, every 15 days was taken as treatment course. The plasma ET and NO was measured before and after the treatments.Result: After the treatments, ET in puerarin group was significantly lower and NO was markedly higher (P <0.01). Compared with control group, ET and NO after treatments in puerarin group changed markedly (P <0.01). Conclusion: Puerarin can decrease plasma ET or increase NO in diabetic patients with microvascular complications.

关 键 词：葛根素 糖尿病 血管病变 血浆内皮素 一氧化氮含量 

分 类 号：R587.1[医药卫生—内分泌]