Graves病患者外周血TNFα的测定及意义  

THE DETERMINATION OF SERUM TNFα IN PATIENTS WITH GRAVES DISEASE AND ITS CLINICAL SIGNIFICANCE

作　　者：逄曙光[1] 孙国建[2] 孙金凤[1] 

机构地区：[1]济南市中心医院内分泌科,济南市250013 [2]滨州医学院附属医院内分泌科

出　　处：《滨州医学院学报》2004年第2期101-102,共2页Journal of Binzhou Medical University

摘　　要：目的 :探讨Graves病 (简称GD )时外周血TNFα的变化及其意义。 方法 :采用双抗体夹心ELISA法测定Graves病患者外周血TNFα的水平。结果 :GD各组血清TNFα水平与正常对照组比较均显著增多 (P <0 0 1 ) ,GD复发组血清TNFα水平低于GD未治疗组 (P <0 0 5 )。结论 :血清TNFα水平在GD时显著升高 ,其升高与甲状腺激素无关 ,而与GD自身免疫过程的活性有关。Objective:To investigate the change of serum tumor necrosis factor α(TNFα) and the relation between TNFα and Graves disease.Methods:TNFα was determined in sera by enzyme linked immunosorbent assay(ELISA).Results:Serum TNFα values increased significantly in untreated GD group compared with those in normal controls and recurrence group.Conclusion:The increase of serum TNFα in untreated GD group has no correlation with thyroid hormone,but has a correlation with autoimmune inflammatory process of Graves disease.

关 键 词：GRAVES病 肿瘤坏死因子α(TNFα) 

分 类 号：R581.1[医药卫生—内分泌]