精浆抗精子抗体阳性不育患者顶体酶及SOD活性的变化  

The change of semen superoxide dismutase (SOD) and acrosin activity in the sterility of male patients with positive antisperm antibody

作　　者：张海峰[1] 张春影[1] 张玮[2] 付宜鸣[1] 袁谭[1] 陈亮[3] 王晓东[1] 

机构地区：[1]哈尔滨医科大学第二临床医学院男科 [2]哈尔滨医科大学生理学教研室 [3]哈尔滨医科大学第二临床医学院生殖中心,黑龙江哈尔滨150086

出　　处：《哈尔滨医科大学学报》2004年第2期172-173,共2页Journal of Harbin Medical University

摘　　要：目的　研究抗精子抗体阳性男性不育患者中顶体酶及SOD活性的变化。方法　应用黄嘌呤氧化酶法 ,测定超氧化歧化酶 (SOD)活性 ,采用BAEE ADH联合法计算精子顶体酶活性。结果　精液抗精子抗体阳性 (AsAb)组与正常生育组比较 ,精液中SOD活性明显降低 ,精子顶体酶活性明显降低。Objective To study the change of semen superoxide dismutase (SOD) and acrosin activity in the sterility of male patients with positive antisperm antibody.Methods The activity of semen superoxide dismutase (SOD) was measured by xanthine oxidase essay and sperm acrosin activity was calculated by BAEE/ADH.Results Compared semen AsAb positive group with normal group, the activity of SOD in semen decreased remarkably, and so did that of acrosomal enzyme.Conclusion The sterility resulting from positive AsAb may be related with the change of semen SOD and acrosin activity.

关 键 词：精浆 抗精子抗体 阳性 不育症 顶体酶 SOD活性 超氧化物歧化酶 AsAb 

分 类 号：R711.6[医药卫生—妇产科学]