大鼠全脑照射后早期大脑皮质MyT1表达及意义  

The Early Phase Expression of MyT1 in the Cortex of Rats After Whole Brain Irradiation

作　　者：李华杰[1] 包仕尧[1] 田野[1] 张志琳[1] 陈列松[1] 

机构地区：[1]苏州大学附属第二医院神经内科,江苏苏州215004

出　　处：《苏州大学学报（医学版）》2004年第1期8-10,共3页Suzhou University Journal of Medical Science

基　　金：国家自然科学基金资助项目 (3 0 170 2 87)

摘　　要：目的　探讨大鼠全脑照射后早期大脑皮质MyT1表达的变化及意义。 方法　SD大鼠单次全脑照射后用免疫荧光组织化学法检测早期大脑皮质MyT1阳性细胞的数量。结果　和对照组相比 ,2Gy、10Gy和 30Gy照射后各时间点大鼠脑皮质内MyT1阳性细胞都有明显的增加 ,其中 10Gy照射后 1周脑皮质区域MyT1阳性细胞增加最明显 ,数量最多。 2Gy、10Gy和 30Gy照射后 1个月 ,脑皮质区域的MyT1阳性细胞较之 1周时减少。 结论　大鼠全脑照射后早期大脑皮质MyT1表达增加 ,并且和照射剂量和观测时间相关。Objective To explore the early phase expression of MyT1 in the cortex of rats after whole brain irradiation. Methods MyT1 positive cells in the cortex of SD rats were determined in early phase after single whole brain irradiation by immunofluorescence histochemistry. Results The number of MyT1 positive cells within the cortex of SD rats increased significantly at each time point post irradiation at doses of 2 Gy, 10 Gy and 30 Gy comparing with that in the control group. The number of MyT1 positive cells of 10 Gy at 1 week after irradiation has the most significant increase in all groups. The number of MyT1 positive cells at all doses decreased at the first month after irradiation comparing with that of 1 week after irradiation. Conclusion The early phase expression of MyT1 in the cortex of rats increases after whole brain irradiation and relates to radiation dose and observing time point.

关 键 词：电离辐射 大脑皮质 髓鞘转录因子1 大鼠 

分 类 号：R818.74[医药卫生—放射医学]