反复自然流产患者血凝变化与抗心磷脂抗体的关系  

A Relationship Between Coagulation and Anticardiolipin Antibodies in Patients with Recurrent Spontaneous Abortion

作　　者：陈洁[1] 沈宗姬[1] 李红[1] 徐文新[1] 华月琴[1] 徐新红[1] 

机构地区：[1]苏州大学附属第一医院妇产科,江苏苏州215006

出　　处：《苏州大学学报（医学版）》2004年第1期68-70,共3页Suzhou University Journal of Medical Science

摘　　要：目的　探讨反复自然流产 (RSA)患者血凝改变与抗心磷脂抗体 (ACA)的相关性。方法　采用金标免疫斑点法测定 4 0例RSA患者和同期 4 0名已育健康妇女 (正常对照组 )的ACA ,并用ELISA法分别检测了她们血浆中的 6 酮 PGF1α、蛋白C(PC)、蛋白S(PS)、AnnexinV抗体的含量。结果　 4 0例RSA组中ACA阳性率为 4 7.5 %。与正常对照组比较 ,RSA组中ACA阳性患者血浆 6 酮 PGF1α、PC、PS水平有不同程度的下降 ,抗AnnexinV抗体的含量升高。结论　ACA阳性患者自然流产的机制可能是ACA致抗凝物质抗凝效应降低 ,舒血管作用减弱 ,血液高凝 。Objective To study relationship between coagulation and anticardiolipin antibodies (ACA) in patients with recurrent spontaneous abortion (RSA). Methods Using enzyme linked immunosorbent assay(ELISA), the levels of 6 K PGF 1α ,protein C(PC), protein S(PS) and anti Anne xin V antibodies(aANX) were measured. Results Compared to normal controls, there exist the levels of 6 K PGF 1α ,PC,PS decreasing and aANX increasing, and ACA positive patients were more prominent than that in the negative case of ACA. Conclusion ACA positive RSA patients may lead to decreasing of anticoagulation effect, and thrombus in the placenta.

关 键 词：反复自然流产 抗心磷脂抗体 6-酮-PGF1Α 蛋白C 蛋白S 抗Annexin V抗体 

分 类 号：R714.21[医药卫生—妇产科学]