乌三颗粒抗肺癌作用及对荷瘤小鼠免疫功能的影响  

Influence of Wusan Granule on Lung Carcinoma and Immunlogical Function Mice Burdening in Tmnor-bearing

作　　者：高丽元 石锦萍 臧志和[2] 辛志伟[2] 

机构地区：[1]第三军医大学成都军医学院实验技术教研室 [2]第三军医大学成都军医学院药学教研室,成都610083

出　　处：《医药导报》2004年第5期295-297,共3页Herald of Medicine

基　　金：四川省教委重点资助项目(基金编号:2000-A71)

摘　　要：目的:探讨鸟三颗粒抗肺癌作用及对荷瘤小鼠免疫功能的影响。方法:采用鸟三颗粒体内对Lewis肺癌抑瘤实验和体外对人肺腺癌细胞、人巨细胞肺癌细胞抑制肿瘤实验相结合的方法,综合评价乌三颗粒抗肺癌作用;以Lewis肺癌小鼠的胸腺、脾脏指数免疫器官指数和白细胞介素-2(IL)-2生成为指标,观察该药对荷瘤小鼠免疫功能的影响。结果:乌三颗粒在体内、外对多种肺癌瘤株有明显的抑制作用;乌三颗粒有明显增加荷瘤小鼠胸腺及脾脏指数、血清IL-2的含量。结论:乌三颗粒在抗肺癌的同时,调节免疫功能是其抗肿瘤的优势。Objective: To study the effects of wusan granule (WSG) on pulmonary carcinoma and immune functions in tumorbearing mice. Methods: The inhibitory effeccts of WSG on Lewis lung carcinoma in vivo and on SPC-A1、A2, SMMC-7721 in vitro were observed. Index of immunologic organs-thymus gland and spleen, and formation of IL-2 in Lewis lung carcinomabearing mice treated with WSG were experimented. Results: Both in vivo and in vitro WSG had definite antitumor effects on several types of tumor cell strains. Index of immunologic orgarts-thymus gland and spleen, and formation of IL-2 in tumor bearing mice were increased significantly. Conclusion: WSG can inhibit proliferation of lung carcinoma, by improving immune functions in mices bearing Lewis lung carcinoma.

关 键 词：乌三颗粒 肺癌 免疫功能 白细胞介素-2 

分 类 号：R285.5[医药卫生—中药学]