中缝大核内微量注射抗催产素血清对电针镇痛的影响  

THE ROLE OF ANTI OXYTOCIN SERUM IN ELECTROACUPUNCTURE ANALGESIA IN THE NUCLEUS TAPHE MAGNUS OF RATS

作　　者：刘文彦[1] 张艳霞[1] 杨媛媛[1] 闫瑞臻[1] 白波[2] 

机构地区：[1]济宁医学院生理学教研室 [2]泰山医学院神经生物学研究室

出　　处：《济宁医学院学报》2004年第1期6-7,共2页Journal of Jining Medical University

基　　金：山东省自然科学基金资助课题 (编号Q98CO112 4)

摘　　要：目的　观察中缝大核 (NRM )内催产素 (OT)对电针镇痛的影响。方法　以钾离子透入法引起大鼠甩尾反应的电流强度 (mA)为痛行为反应指标 ,测定动物痛阈 ,观察NRM内催产素对电针镇痛的影响。结果　NRM内微量注入抗催产素血清后 ,大鼠电针镇痛的效应明显减弱 ;与注射正常兔血清相比 ,有显著性差异。结论　NRM内的催产素在电针镇痛的复杂过程中发挥着一定作用。Objective To study the effect of Oxytocin(OT)on electroacupuncture analgesia in nucleus raphe magnus(NRM).Methods The potassium iontophoresis induced tail-flick was used to measure the pain threshold.The effet of NRM injection of anti-OT serum (AOTS)on the pain threshold in the rat was investigated.Results Injection of AOTS reduced the electroacupuncture analgesia significantly.Conclusion There results indicate that OT in NRM is involved in electroacupuncture analgesia.

关 键 词：中缝大核内微量注射 抗催产素血清 电针镇痛 大鼠 痛阈 

分 类 号：R245.31[医药卫生—针灸推拿学] R441.1[医药卫生—中医临床基础]