固安县献血(浆)者HCV和HBV感染的血清学追踪观察  

Serologic Follow-up Survey of Hepatitis C Virus and Hepatitis B Virus Infection in Plasmapheresis Donors in Guan County

作　　者：王东济 陈素良 孙永德 孙德贵 陈学儒[1] 胡宗汉[4] 王素玉[1] 孟宗达 刘彩云 史蕰华 邱贺民[1] 

机构地区：[1]廊坊市人民医院,102800 [2]河北省卫生防疫站 [3]固安县卫生防疫站 [4]卫生部药品生物制品检定所

出　　处：《中国输血杂志》1992年第4期180-183,共4页Chinese Journal of Blood Transfusion

摘　　要：1985年固安县献浆者中发生丙型肝炎流行。1986年初,调查了该县当年(1985年)献浆村、献浆5年村和基本无献血村的献浆者和献全血者HCV和HBV的感染状况,1990年又追踪观察。结果是1986年和1990年献浆者抗-HCV阳性率分别为64.7％和43.9％。在献浆者中ALT异常的抗-HCV阳性率分别为77.5％和81.1％;ALT正常的分别为51.3％和34.3％。献浆者抗-HCV阳性率均高于献全血者和非献血成人。提出在固安县供血单位增加抗-HCV筛选献血者势在必行。另外对91例抗-HCV阳性献浆者第5年又进行了追踪观察,阴转率为30.8％,约有70％的病例转为慢性。An epidemic of hepatitis C virus occurred in plasmapheresis donors on Guan county in 1985. Early on 1986, there were investigated the state of hepatitis C virus and hepatitis B virus infection in plasmapheresis and whole blood donors from the villages with plasmapheresis donation in that year 1985, the villages with five-year plasmapheresis donation and the villages bacially without blood donation, then the follow-up survey of them was made in 1990. The positive rates of anti-HCV for plasmapheresis donors in 1986 and 1990 were 64.7% and 43.9% respectively. The positive rates of anti-HCV in the plasmapheresis donors with abnormal ALT were 77.5% and 81.1% and in the plasmapheresis donors with normal ALT were 51.3% and 34.3%. The positive rate for anti-HCV in plasmapheresis donors was higher than that in the whole blood donors and controls. It was proposed that the increasing of anti-HCV screening in blood supplying villages was imperative. In addition, the follow-up survey of 91 anti-HCV positive plasmapheresis donors was made in the fifth year since then, the rate at which the positive results turned to negative was 30.8%, about 70% cases turned out to chronic.

关 键 词：血浆 丙型肝炎病毒 抗体 献血员 

分 类 号：R457.12[医药卫生—治疗学]