芍丹乙肝颗粒成型工艺的研究  

Study on formulation process of Shaodanyigan Granule

作　　者：赵军[1] 沈季元[1] 李景庄[1] 张帆[2] 

机构地区：[1]新疆医科大学第一附属医院药剂科,新疆乌鲁木齐830054 [2]巴州人民医院药剂科,新疆库尔勒841000

出　　处：《新疆医科大学学报》2004年第2期169-170,共2页Journal of Xinjiang Medical University

摘　　要：目的 :确定芍丹乙肝颗粒剂的最佳制粒处方组成。方法:以颗粒吸湿百分率、成型率和溶化率为指标 ,筛选颗粒最佳辅料与配比。结果 :处方最佳组成为 :1份浸膏粉与 2份辅料 (乳糖∶甘露醇 =4∶ 1的混合辅料 )。所制颗粒吸湿率小 ,成型率高 ,溶化率高 ,临界相对湿度约为 72 %。Objective: To ascertain the best formulation process of Shaodanyigan Granule. Methods: By determinating hygroscopicity,granulation and dissolubility, the appropriate excipient and its formula were selected. Result: The best excipient and its formula were one extract and two excipients which consisted of lactose and mannitol (4∶1, w/w). The made granules have low hygroscopicity and high granulation and high dissolubility. And its critical relative humidity is 72% or so. Conclusion: The experimental results provide the basis of the ascertainment of formulation process and the control of production enviroment of Shaodanyigan Granule

关 键 词：芍丹乙肝颗粒 成型工艺 临界相对湿度 

分 类 号：R978.7[医药卫生—药品] R94[医药卫生—药学]