混合型人工肝支持系统治疗慢性重型肝炎疗效研究  

Study of Severe Hepatitis Treated with a Hybrid Artificial liver Support System

作　　者：李兰娟[1] 杨芊[1] 黄建荣[1] 李君[1] 曹红翠[1] 陈月美[1] 陈亚岗[1] 盛吉芳[1] 付素珍[1] 

机构地区：[1]浙江大学医学院附属第一医院,浙江杭州310003

出　　处：《透析与人工器官》2004年第1期21-24,共4页Chinese Journal of Dialysis and Artificial Organs

摘　　要：目的 :评价混合型人工肝支持系统治疗慢性重型肝炎患者的临床疗效。方法 :应用内含5× 10 9以上猪肝细胞的生物反应器结合血浆置换装置 ,构建混合型人工肝支持系统 (HALSS) ,用于治疗 15例慢性重型病毒性肝炎患者。结果 :每次治疗后患者临床症状不同程度减轻 ,乏力、腹胀明显改善 ,腹水减少。总胆红素在混合型人工肝支持系统治疗后有明显下降 ,凝血酶原活动度上升。 15例患者中 11例经混合型人工肝支持系统治疗肝支持系统治疗肝细胞迅速坏死得到控制 ,最终好转出院 ,4例患者病情无好转死亡。 15例患者治疗中未发生严重不良反应。结论Objective To evaluate the efficacy of a hybrid artificial liver support system in the treatment of chronic severe hepatitis.Methods:The hybrid artificial liver support system(HALSS) consists of a bioreactor containing of more than 5×10 9 porcine hepatocytes and plasma exchange device.15 patients with chronic severe viral hepatitis were treated with the hybrid system.Results:All patients experienced a reduction in symptoms such as fatigue,abdominal distention or ascites.After each treatment serum total bilirubin decreased markedly while prothrombin activity increased.There were 11 patients whose progress of hepatocytes necrosis were stopped after HALSS treatment,and finally they recovered completely.Four patients died because of their worsen conditions.No serious adverse events were noted in the fifteen patients.Conclusions:HALSS is a reliable hepatic support device for chronic severed hepatitis.

关 键 词：混合型人工肝支持系统 治疗 慢性重型肝炎 血浆置换 病毒性肝炎 

分 类 号：R512.6[医药卫生—内科学]