人工肝支持系统治疗重型病毒性肝炎的疗效评估  

A Clinical Assess of Artificial Liver Supporting Systems on Patients with Fatal Hepatitis

作　　者：鲁朝晖[1] 章秋霞[1] 常立非[1] 高人焘[1] 吴晓玲[1] 李宜[1] 徐少保[1] 

机构地区：[1]安徽省立医院传染科,安徽合肥230001

出　　处：《透析与人工器官》2004年第1期34-37,共4页Chinese Journal of Dialysis and Artificial Organs

摘　　要：目的 :探讨人工肝支持系统 (ALSS)对重型肝炎的疗效。方法 :应用人工肝支持系统(WLXGX- 888)对 2 3例重型病毒性肝炎进行了 5 2例次的治疗。根据病情分别选择血浆置换、血液灌流、血浆吸附和血液滤过 4种治疗方法。比较治疗前后临床表现和血浆总胆红素 (TBIL )、血氨(NH3 )、肿瘤坏死因子 - α(TNF- α 水平、凝血酶原活动度 (PTA)、丙氨酸转氨酶 (ALT)、白蛋白(ALB)。选择同期住院病情相近的病例 2 0例为对照组。结果 :治疗后症状明显改善 ,血总胆红素(TBIL)、血氨 (NH3 )、肿瘤坏死因子 - α(TNF- α)水平明显下降 ,凝血酶原活动度 (PTA)明显上升。治疗组有效率为 6 9.6 % ,对照组有效率为 35 .0 % (p<0 .0 5 )。人工肝支持系统治疗的不良反应在处理后均能好转。结论 :人工肝支持系统治疗重型肝炎能有效改善临床症状、显著改善生化指标 ,降低 TNF-α水平 ,提高近期存活率 ,是一种安全可行的治疗方法。Objective Probing the curing effects of artificial liver supporting systems(ALSS) treatment on fatal hepatitis.Methods:Treat 23 fatal viral hepatis cases with ALSS(WLXGX 888)for 52 times.To compare the clinical manifestation and blood levels of TBIL,NH 3,TNF α,ΡΤΑ,ΑLΤ,ΑLΒ prior to and subsequent to the treatment.The control group consists of 20 cases of similar patients who were admitted to the hospital during the same period of time.Results:After treatment the symptoms were effectively improved.The blood level of TBIL,NH 3,TNF α show significant decrease and the level of PTA increases.69.6% at effectual rate in the treatment group,but 35.0% in the control group.After available treatment the untoward effect takes a favorable recovery.Conclusion:Artificial liver supporting systems on the treatment of fatal hepatitis can effectively improve the clinical symptoms,remarkably improve the biochemical indicators,reduce TNF α and increase the short term survival percentage.ALSS is indeed an effective and safe treatment for fatal hepatitis.

关 键 词：人工肝支持系统 治疗 重型病毒性肝炎 疗效 血浆置换 血液灌流 

分 类 号：R512.6[医药卫生—内科学]