湖北移植与云南原产鞘蕊苏平喘药效学比较  

Comparison of the pharmacodynamics between transplanted (Hubei) and original (Yunan) Coleus Forskolin Briq. on relieving experimental asthma

作　　者：吴勇[1] 陈金和[1] 

机构地区：[1]武汉大学医学院药理学系,湖北武汉430071

出　　处：《中国医院药学杂志》2004年第4期211-212,共2页Chinese Journal of Hospital Pharmacy

基　　金：湖北省科技攻关计划项目 (编号 :2 0 0 3AA3 0 2B17)

摘　　要：目的 :对湖北移植鞘蕊苏与原产地云南会泽县鞘蕊苏平喘作用进行药效学比较。方法 :采用喷雾致喘法 ,豚鼠组胺致喘模型 ,比较两产地鞘蕊苏等生药量、等浸膏量平喘作用及量效关系。结果 :两产地鞘蕊苏相等生药量、等浸膏量均能显著延长豚鼠组胺致喘潜伏时间 (P <0 .0 1 ) ,平喘作用、量效关系基本相似。急性毒性试验结果表明 :湖北移植鞘蕊苏小鼠灌胃最大耐受量为 2 5 9.2 g(含生药量 )·kg-1 ,云南产鞘蕊苏最大耐受量为 1 1 5 .0 g(含生药量 )·kg-1 。结论 :两产地鞘蕊苏相等生药量、等浸膏量平喘作用、量效关系基本相似 ,均无明显毒性。OBJECTIVE To compare the pharmacodynamics between transplanted (Hubei) and original (Yunan) Coleus Forskolin Briq. METHODS Causing asthma in guinea pig by spraying histamine to compare the effect on relieving experimental asthma and dose effect relationship of equal dose of raw drug and extract between transplanted (Hubei) and original (Yunan) Coleus Forskolin Briq. RESULTS Coleus Forskolin Briq from both provinces (Hubei and Yunan) could significantly prolong the latent time of the experimental asthma of guinea pig induced by histamine ( P < 0.01 ). Their effects on relieving asthma and dose effect relations were similar. Test for acute toxicity suggested that by intragastric feeding of Hubei transplanted Coleus Forskolin Briq , in guinea pig, the maximum tolerance dose was 259.2 g ·kg -1 . While by feeding of Yunan Coleus Forskolin Briq , the maximum tolerance dose was 115.0 g ·kg -1 .CONCLUSIONS The effects on relieving experimental asthma and dose effect relationship of equal dose of raw drug and extract between transplanted (Hubei) and original (Yunan) are similar, they both have no significant toxicity.

关 键 词：鞘蕊苏 平喘作用 急性毒性试验 

分 类 号：R961[医药卫生—药理学]