无锡市2001年～2002年度流感监测分析  

Analysis of influenza surveillance during 2001-2002 ,WuxI City

作　　者：缪小兰[1] 陈恩品[1] 胡遴[1] 尤风兴[1] 董美华[1] 李军[1] 任智红[2] 徐亚敏[3] 张文秀[2] 沈小静[3] 

机构地区：[1]无锡市疾病预防控制中心,江苏无锡214002 [2]无锡市第一人民医院,江苏无锡214000 [3]无锡市第三人民医院,江苏无锡214000

出　　处：《江苏预防医学》2004年第1期1-3,共3页Jiangsu Journal of Preventive Medicine

摘　　要：目的 :监测分析我市流行性感冒的流行和流感病毒变异情况 ,为流感防治对策提供理论依据。方法 :①疫情监测 ,设立哨点医院 ,在内科、儿科门诊监测流感样病例和肺炎病例 ;②病原学监测 ,用鸡胚双腔对监测标本做病毒分离 ,用微量血凝抑制试验 (HI)进行型别鉴定 ;③血清学监测 ,采集不同年龄组的自然人群血清 ,检测甲 1型、甲 3型和乙型流感病毒抗体水平 ,以血凝抑制抗体滴度≥ 1∶10判为阳性 ,滴度≥ 1∶4 0判为有保护性作标准。结果 :监测期间疫情基本平稳 ,2 0 0 1年冬曾出现一个流感样病例发病高峰 ,同时伴随肺炎发病增高。发病构成≤ 14岁占 90 .71% ,≥ 6 0岁较低。2 0 0 1年 10月～ 2 0 0 2年 3月分离出 2株甲 1型流感病毒 ,型别为A1/沪防 / 7/ 99;2 0 0 2年 10月～ 2 0 0 3年 3月分离出流感病毒 7株 ,型别均为B型 ,其中 6株为B/Yamanashi/ 16 6 / 98,1株为B/Victoria。毒株分离出时间与流感样病例发病高峰相一致 ,标本源于 13岁以下患者。人群抗体监测 ,甲 3型流感抗体水平较高 ,抗体阳性率≥ 87 0 5 % ;甲 1型抗体阳性率偏低≤ 2 7 38% ;乙型抗体阳性率 2 0 0 2年为2 1 13% ,明显低于 2 0 0 1年的 74 85 %。结论 :本地人群对甲 1和乙型流感缺乏免疫力 ,下一流行季节存在甲Objective: To analyze the data of influenza surveillance and the trend of virus mutation so as to establish the defending system for preventing influenza effectively. Method: 1. A hospital was selected and collected all respiratory cases and pneumonia cases from internal medicine and pediatrics. 2.Chicken embryo was used to isolate the influenza virus and the virus was identified by HI test. 3. Serum samples were taken from people of different age and the titles of antibodies to influenza type A1(H1N1), typeA3(H3N2) and type B were detected. HI titer≥1∶10 is considered positive, HI titer ≥1∶40 is considered protective. Result: The curve of respiratory cases were even during the period of monitoring, but there was a peak season during the winter of 2001. The curve of pneumonia cases had a peak correspondingly. 0~14 age group was 90.71%, ≥60 age group was the least. There were 2 strains of A1 type viruses were isolated form October 1, 2001 to Mar 31, 2002. 6 strains of B/Yamanashi/166/98 and 1 strain of B/Victoria were isolated form October 1, 2002 to March 31, 2003. When the viruses were isolated, just the same time with influenza peak season occured. And the patients were all children < 13 years old.Conclusion: A1 type and B type influenza virus antibodies level were lower in the local population, so A1 type and B type are likely to spread during the next epidemic period.

关 键 词：无锡市 2001年 2002年 流行性感冒 流感抗体 流行病学 病原学 

分 类 号：R511.7[医药卫生—内科学]