Waldenstrm巨球蛋白血症病理细胞的特殊形态学改变二例报告  

Special Morphological Changes of Pathologic Cells in Two Cases of Waldenstrm′s Macroglobulinemia

作　　者：陈学良[1] 李芳邻[1] 赵川莉[1] 姜道滋[1] 秦平[1] 王应玞[1] 闫树昕[1] 

机构地区：[1]山东大学齐鲁医院肿瘤中心血液科,济南250012

出　　处：《中国实验血液学杂志》2004年第2期220-223,共4页Journal of Experimental Hematology

摘　　要：Waldenstr m巨球蛋白血症 (WM)是由B淋巴细胞克隆异常增殖所致的血液系统恶性肿瘤 ,其病理细胞具有分泌单克隆免疫球蛋白M的功能。本研究对 2例WM患者的诊断经过及形态学特点进行了分析。结果表明 ,2例患者的细胞学检查均发现特殊的“泡沫状细胞” ,其细胞化学染色具有淋巴细胞的特征 ,而不具有单核巨噬细胞或脂肪细胞的特点。结论 :本文所描述的细胞为印戒样淋巴细胞的特殊亚型 ,可以将其描述为“宝石镶戒样淋巴细胞”。Waldenstrm′s macroglobulinemia (WM) is one of malignant hematological disease on account of abnormal proliferation of B lymphocyte clone and the pathologic cells of WM possess ability to secrete monoclonal immunoglobulin M. In this study, the diagnosis and morphological characteristics of 2 patients with WM were analyzed. The results showed that a special kind of 'foam cells' were found by cytochemical staining examinations in both cases, which displayed characteristics of lymphocytes, but neither monocyte macrophage nor fatty cells. The periodic acid Shiff′s reaction (PAS) demonstrated strong positive, especially on the inclusion bodies in pathologic cell plasma while the acid phosphatase, and alpha butanoic acetate esterase stainings, resulted both in negative. In conclusion, the cells found in the two cases reported may be described as gemmy ring like lymphocyte in morphology, a special subtype of ring like lymphocyte.

关 键 词：Waldenstroem巨球蛋白血症 巨球蛋白血症 印戒样淋巴细胞 

分 类 号：R553[医药卫生—血液循环系统疾病]