中药对急性耐力运动大鼠脑组织血清素及其代谢能力的影响  

Influence of Chinese Herb on Serotonergic and Its Metabolation Ability in Different Brain Region in Rat After Acute Endurance Exercise

作　　者：宋亚军[1] 孙勤枢[2] 王鲁克[1] 王宁[2] 梁玉记[3] 

机构地区：[1]山东济宁师专体育系,山东济宁272000 [2]山东济宁医学院化学教研室,山东济宁272000 [3]山东济宁医学院药理教研室,山东济宁272000

出　　处：《深圳中西医结合杂志》2004年第2期72-75,共4页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

基　　金：山东省教育厅科技计划项目(No:J01K54)

摘　　要：目的为运动、中医药与中枢疲劳的研究提供依据。方法以端脑、间脑和脑干5-HT、5-HIAA等指标为研究对象,探讨补充中药对急性耐力运动大鼠脑组织血清素及其代谢能力的影响。结果3h游泳后即刻,大鼠端脑、间脑和脑干5-HT、5-HIAA含量和5-HT/5-HIAA比值对急性耐力运动的反应表现为非均衡性和区域特异性。通过复方中药的应用,使大鼠各脑区5-HT对急性耐力运动反应的敏感性降低,对急性耐力运动中5-HT的分解代谢过程、递质更新率及神经元活性产生积极性影响。结论该复方中药对推迟急性耐力运动中中枢疲劳的产生可能具有一定的积极性作用。Objective To Provide evidence for study of exercise, TCM and Central fatigue. Methods Toobserve the change of 5-HT and 5-HIAA and 5-HT/5-HIAA immediately after acute endurance exercise, and inquired into the influence of Chinese herb on 5-HT and its products of metabolisms in different brain region in rat. Results The compound of Chinese herb could reduce the content of 5-HT in some brain region in rat, and could bring into play the positive effect on postponing central fatigue after acute endurance exercise. Conclusion The complement of the Chinese herb compound had positive effect to the process of metabolisms and the ratio of renewal of the serotonin and the active of the nerve cell after acute endurance exercise. 〔

关 键 词：急性耐力运动 不同脑区 5-羟色胺 5一羟吲哚乙酸 中药 中枢疲劳 

分 类 号：R285.5[医药卫生—中药学]