严重急性呼吸综合征患者血浆纤维结合蛋白的测定  

A SHARP DECLINE OF PLASMA FIBRONECTIN IN ACUTE STAGE PATIENTS WITH SEVERE ACUTE RESPIRATORY SYNDROME(SARS) AND ITS TREATMENT

作　　者：刘景汉[1] 欧阳锡林[1] 田亚平[1] 于洋[1] 马曙轩[1] 王海宝[1] 宋淑珍[1] 李晖[1] 

机构地区：[1]解放军总医院,北京100853

出　　处：《解放军医学杂志》2003年第9期785-786,共2页Medical Journal of Chinese People's Liberation Army

摘　　要：目的　探索严重急性呼吸综合征(SARS)患者急性期血浆纤维结合蛋白的变化及输注血浆纤维结合蛋白治疗急性期SARS的可行性。方法　对照组为 2 4名体检合格的无偿献血者 ;实验组为 4名住院的急性期SARS患者。采用ELISA法测定两组血浆纤维结合蛋白水平。结果　对照组血浆纤维结合蛋白为 476 2± 2 2 1 0mg/L ,SARS组为 42 2± 2 3 0mg/L ,两组差异有显著性意义 (P <0 0 1)。结论　急性期SARS患者血浆纤维结合蛋白水平显著降低 ,为输注外源性的纤维结合蛋白治疗SARS提供了依据。Objective To explore the changes in plasma fibronectin level in patients with SARS in the acute stage, and the feasibility of the use of plasma fibronectin in acute stage of SARS. Methods Plasma fibronectin contents were assayed with ELISA in patients with SARS in acute stage and 24 healthy donors. Results The plasma fibronectin level of control group was 476.2±221.0mg/L, while that of four SARS patients was 42.2±23.0 mg/L(P<0.01). Conclusion The results showed that the level of plasma fibronectin in 4 patients with SARS in acute stage was remarkably lowered compared with the healthy subjects. The result suggested that plasma fibronectin level was lowered considerably in patients with SARS in acute stage, and therefore supplementation of fibronectin might be indicated in such patients.

关 键 词：严重急性呼吸综合征(SARS) 纤连蛋白类 输血 

分 类 号：R563.1902[医药卫生—呼吸系统]