生育三烯酚的研究进展  

Progression of tocotrienols

作　　者：孙文广[1] 阎雅更[1] 董凤利[1] 

机构地区：[1]哈尔滨医科大学第一临床医学院,哈尔滨150001

出　　处：《卫生研究》2004年第2期243-245,共3页Journal of Hygiene Research

摘　　要：生育三烯酚是生育酚的同分异构体 ,由一个色原烷醇核和一个亲脂性的异戊二烯链构成。生育三烯酚在棕榈油、大米麸中富含。具有抗氧化、抑制脂质过氧化性 ;通过抑制胆固醇合成途径关键酶羟甲基戊二酸单酰CoA还原酶 (HMGCoA还原酶 )的活性 ,降低胆固醇的合成 ;并有抗肿瘤和神经保护作用。本文综述了生育三烯酚的分子结构及生物学功能。Tocotrienols is an isoform of tocopherols. Tocotrienols consists of a chromanol nucleus and a lipophilic isoprenoid chain. Tocotrienols were found in high concentrations in palm oil and rice bran. Its discovery was mainly antioxidant and resistant to lipid peroxidation. Tocotrienols influenced cholesterol synthesis by directly regulated activity of 3 hydroxy 3 methylglutaryl coenzyme A reductae (HMG CoA reductase) and decreased cholesterol. Important novel antiproliferative and neuroprotective effects have found. Molecular structure and biological function of tocotrienols were reviewed in this paper.

关 键 词：生育三烯酚 HMGCoA还原酶 抗肿瘤 谷氨酸 

分 类 号：Q566[生物学—生物化学]