血组胺动态测定对急性心肌梗塞早期诊断意义的探讨  

EVALUATION OF EARLY DIAGNOSIS OF AMI BY DYNAMIC ASSESSMENT OF HISTAMINE

作　　者：齐晓勇[1] 王学忠[1] 夏岳[1] 甄胜西[1] 韩玉平[1] 谷剑[1] 樊瑞芹 高羽 

机构地区：[1]河北省医院 [2]河北省计划生育研究所

出　　处：《中国循环杂志》1992年第2期133-136,共4页Chinese Circulation Journal

摘　　要：本文动态测定了36例急性心肌梗塞(AMI)患者血组胺、肌酸磷酸激酶(CPK)及同功酶(CPK-MB)、乳酸脱氢酶(LDH)和天门冬氨酸转氨酶(AST)。结果表明,AMI发病后1～4 (平均2.2±1.2)h血组胺出现异常值,20.2±6.5h上升至峰值,52.6±16.6h下降至正常。36例AMI血组胺峰值平均为4.19±1.35μmol/L,显著高于正常上限(>3.6倍)。血组胺变化明显早于CPK-MB(P<0.01)。14例组胺出现异常值<3h,峰值时间<18h,3例峰值>4.50μmol/L者合并室性心律失常,反之仅占27.27%(P<0.01)。我们认为,血组胺动态测定对AMI早期诊断及缺血性心律失常预测有重要意义。Dynamic assessment of blood histamine, serum creatine phosphokinase (CPK), lactate dehydrogenase (LDH) and aspartate transaminase (AST)in 36 cases of acute myocardial infarction (AMI) was reported. Blood histamine level elevated within 1—4 (average 2.2±1.2) hours after onset of chest pain with peak levels reached within 20.2±6.5 hours and returned to normal level within 52.6±16.6 hours, the averge peak levels were 4.19±1.35 μmol/L (46.56±15.06 μg/dl). The results showed that blood histamine changes were earlier than CPK-MB in AMI (p<0.01). The sensitivity of diagnosis for AMI was 100%, specificity was 86.96%. 14 cases with elevated histamine within 3 hours after onset of chest pain, peak levels of 4.50 μmol/L (50μg/dl) within 18 hours were all complicated by ventricular arrhythmias (100%), versus 27.27% in the rest (p<0.01). It suggests that histamine is a very important parameter for the diagnosis of AMI and prediction of ischemic arrhythmias.

关 键 词：心肌梗塞 血组胺 动态测定 

分 类 号：R542.220.4[医药卫生—心血管疾病]