单、复方阿米洛利对心力衰竭的保钾利尿作用  

POTASSIUM-SPARING DIURETIC ACTION OF PURE AND COMPOUND AMILORIDE IN PATIENTS WITH HEART FAILURE

作　　者：陆德澄[1] 余文宪 杨显祖 赵福全[4] 洪立基[5] 汤永祥[1] 苏子杰[1] 陈二南[1] 凌玲[1] 隋风[1] 孙广辉[1] 张树春[1] 候建民[1] 任国庆[1] 张敬铭 戴玉瑛 

机构地区：[1]镇江医学院附属医院 [2]溧阳制药厂 [3]常州市第一医院 [4]扬州医学院附属医院 [5]南京医学院卫生统计教研室 [6]扬中县人民医院

出　　处：《中国循环杂志》1992年第4期333-335,共3页Chinese Circulation Journal

摘　　要：单、复方阿米洛利治疗心力衰竭109例,采用双盲、随机、分层自身及组间对照,疗程两周,分四个组:Ⅰ组阿米洛利5mg加氢氯噻嗪(双氢克尿塞)50mg/日;Ⅱ组阿米洛利5mg加氢氯噻嗪25mg/日;Ⅲ组阿米洛利10mg分2次服;Ⅳ组氨苯蝶啶50mg,每日3次。结果:四个组均有保钾利尿作用,但Ⅰ组利尿作用优于Ⅱ和Ⅲ组.Ⅲ组优于Ⅳ组(P<0.01及P<0.05)。Ⅲ组保钾作用较好,自身前后血钾P<0.05。四个组尿钾排出均较治疗前减少,自身对照P均<0.01。Ⅰ、Ⅱ、Ⅲ组中共7例治疗后室早消失。其中4例原有低钾心电图表现者亦恢复,故认为此药对心力衰竭保钾利尿作用良好。One hundred and nine cases of heart failure were treated with single or compound amiloride by double-blind and randomization for two weeks.Patients were divided into four groups: (1) amiloride 5 mg plus dihydrochlorothiazide 50 mg/day (group Ⅰ), (2) amiloride 5 mg plus dihydrochlorothiazide 25 mg/day (group Ⅱ), (3) amiloride 5 mg b. i. d. (group Ⅲ), (4) triamterene 50 mg t. i. d. (group Ⅳ).Results: Potassium-sparing and diuretic actions were found in all of the four groups, but the diuretic action of group Ⅰ was superior to that of group Ⅱ and group Ⅲ, and group Ⅲ was superior to group Ⅳ (P<O.01 and P<O.05, respectively). Potassium-sparing action in group Ⅰ was the strongest among the 4 groups. Urinary potassium concentrations were significantly decreased among all of the groups. All cases (7) with premature ventricular beats were controlled after treatment. Hypokalemic ECG in 18 cases became normal.Amiloride is a new diuretic. Treatment of heart failure by compound amiloride (amiloride plus dihydrochlorothiazide 50 mg) is satisfactory.

关 键 词：阿米洛利 心力衰竭 保钾利尿剂 

分 类 号：R541.605[医药卫生—心血管疾病]