纳洛酮在急性重型颅脑损伤中的应用  

The application of naloxone in acute severe brain injuries

作　　者：林坚[1] 周景义[2] 林露阳[1] 

机构地区：[1]浙江省温州医学院附属第二医院 [2]浙江大学医学院附属第二医院

出　　处：《浙江创伤外科》2004年第2期74-75,共2页Zhejiang Journal of Traumatic Surgery

摘　　要：目的探讨纳洛酮治疗急性重型颅脑损伤的效果。方法对67例急性重型颅脑损伤病人随机分组对照,观察两组病人生命体征和意识状态变化,并进行统计学分析。结果实验组病例入院3天后平均动脉压异常率为23.5%,呼吸异常率为11.8%,心律异常为29.4%,明显较对照组少。伤后48小时意识转清率实验组与对照组分别是32.4%与30.0%,两者无明显差别。1周后意识转清率实验组64.7%,明显高于对照组48.6%。结论纳洛酮治疗急性重型颅脑损伤,有利于较快恢复生命体征稳定,缩短昏迷时间。Objective To study the effect of naloxone on acute severe brain injuries. Methods 67 patients were divided into treatment group(34 cases) and control group(33 cases) in random to observe the fluctuation of vital signs and state of consciousness. Results The fluctuation of vital signs in the first 3 days was smoother in treatment group than that in control, including the incidences of abnormal aspiration (4/7, P<0.05) arrhythmia control group (23 cases) were higher than that in control group(16 cases) after 7 days. Conclusion Naloxone was conducive to steady recovery of vital signs and to perfect awaken-function for acute severe brain injuries.

关 键 词：纳洛酮 急性重型颅脑损伤 药物治疗 生命体征 意识状态 

分 类 号：R651.15[医药卫生—外科学] R979.3[医药卫生—临床医学]