曲美他嗪治疗缺血性心脏病心绞痛的疗效观察  

Curative effect of trimetazidine on ischemic heart disease with angin a pectoris

作　　者：钟丽华[1] 艾银红[1] 赵环宇[1] 刘洋[1] 崔艳[1] 

机构地区：[1]哈尔滨医科大学第四临床医院心内科,150010

出　　处：《中国基层医药》2004年第2期146-147,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的　评价曲美他嗪对缺血性心脏病、心绞痛的临床疗效。方法　缺血性心脏病心绞痛病人118例 ,随机分为A、B两组 ,A组给予常规治疗 ;B组在常规治疗基础上加服曲美他嗪 2 0mg ,1日 3次 ,并观察下述指标 :①静息心电图 ;②心绞痛发作的次数 ;③心绞痛发作持续的时间 ;④不良反应。结果　B组可明显改善静息心电图心肌缺血的表现 ,总有效率为 80 3 % ,与A组比较差异有显著意义 (P <0 0 5) ;B组能缓解心绞痛发作的次数及缩短心绞痛的持续时间 ,与A组比较差异有显著意义 (P <0 0 5)。结论　曲美他嗪作为心肌细胞能量代谢优化剂 ,使用安全 ,值得临床推广。ObjectiveTo evaluate the clini cal efficacy of trimetazidine in treating ischemic heart disease with angina pec toris.MethodsA total of 118 patients with angina pectoris were randomly divided into group A and group B.Routine anti-ischemia therapy were g iven to group A.Group B took trimetazidine 20mg(three times a day).The following indexes were observed:(1)The presentation of myocardial ischemia in resting ele ctrocardiogram.(2)Times of angina pectoris attack.(3)Duration of angina pectoris attack.(4)Abnormal reactions.ResultsIn group B 80.3% of patie nts had an obvious improvement in resting electrocardiogram.Compared with group A,the presentation of myocardial ischemia in resting electrocardiogram improved significantly(P<0.05),times and duration of angina pectoris att ack decreased obviously(P<0.05).ConclusionTri metazidine served as a drug for optimizing the enenrgy metabolism of myocardial cell is worth using widely and safely.

关 键 词：曲美他嗪 药物治疗 缺血性心脏病 心绞痛 心电图 不良反应 

分 类 号：R541.4[医药卫生—心血管疾病] R972[医药卫生—内科学]