支气管哮喘患儿血内皮素-1和一氧化氮水平测定及临床意义  

Study on the significance of the asthmatic children's endothelin-1 and nitric oxide level in the serum

作　　者：骆志平[1] 陈莉[1] 吴伟城[1] 李程[1] 

机构地区：[1]广东深圳市龙岗中心医院儿科,518116

出　　处：《中国基层医药》2004年第2期158-159,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的　探讨内皮素 1(Endothelia 1,ET 1)和—氧化氮 (nitrcoxide ,NO )在儿童哮喘发病机制中的作用。方法　对 40例支气管哮喘患儿和 40例正常儿童进行了血浆ET 1及血清NO水平检测。结果　哮喘急性期患儿血ET 1和NO明显高于缓解期 (P <0 0 1) ,缓解期ET 1和NO虽有所下降 ,但仍高于对照组(P <0 0 5)。结论　ET 1和NO水平与哮喘病情严重程度成正相关 。ObjectiveTo study the role of plasma endothelin-1(ET-1) and nitric oxide(NO) in the pathogenesis of the asth matic children.MethodsThe ET-1 and NO were measured by using specific radioimmunoassay and colorimetry in 40 children with asthma and 30 heal th controls.ResultsThe plasma levels of ET-1 and NO in asthma tic acute attack stage was significant higher than those in control group(P<0.01),while in relieving stage the ET-1 and NO levels decreased bu t still higher than those in control group(P<0.05).Conc lusionET-1 and NO play important roles in pathologenesis of bronchial asthma.The plasma levels of ET-1 and NO are the indicators to judge the status of bronchial asthma.

关 键 词：支气管哮喘 小儿 内皮素-1 一氧化氮 测定 血浆 

分 类 号：R725.6[医药卫生—儿科]