槲皮素磷酸酯钾对实验性心肌梗塞的影响  

EFFECTS OF PQP ON EXPERIMENTAL MYOCARDIAL INFARCTION IN RABBITS

作　　者：汤允昭[1] 陶然[1] 郝一彬[1] 张萍[1] 王志平[1] 梁克军 

机构地区：[1]山西医学院药理教研室,太原030001 [2]厦门鱼肝油厂,福建361005

出　　处：《中国药理学通报》1992年第1期69-72,共4页Chinese Pharmacological Bulletin

摘　　要：iv10～20mg/kg(木解)皮素磷酸酯钾使兔急性心肌梗塞范围明显缩小,ST段明显降低,并能对抗冠脉结扎后引起的血清CPK含量增加及心律失常,这些作用与普萘洛尔相似。但iv40mg/kg后作用不明显。Potassium quercetin phosphate ( PQP, iv 10~20mg/kg ) significantly decreased the size of infarction and S-T segment elevation induced by coronary artery ligation in rabbits (P<0.05), meanwhile PQP could reduce the plasma CPK activity and ventricular arrhythmias induced by coronary artery ligation (P<0.05). These effects are similar to those of propranolol. But PQP (iv 40mg/kg) couldn't obviously influence them. The above results suggeste that PQP ( iv 10~20mg/kg ) is beneficial and safe in limitation of EMI size and antiarrhythmia.

关 键 词：槲皮素 磷酸酯钾 心肌梗塞 

分 类 号：R965[医药卫生—药理学]