人参二醇组皂甙对内毒素性休克保护作用机制的实验研究  

MACHANISM OF PROTECTIVE EFFECTS AGAINST ENDOTOXIC SHOCK BY THE PANAXAKIOL SAPONIN

作　　者：刘媛媛[1] 许昶[1] 吕美德[1] 赵雪俭[2] 李扬[2] 赵丹[2] 

机构地区：[1]白求恩医科大学一院传染科,长春130021 [2]白求恩医科大学病生教研室,长春130012

出　　处：《中国药理学通报》1992年第1期60-63,共4页Chinese Pharmacological Bulletin

摘　　要：将粗制大肠杆菌内毒素注入大鼠腹腔复制休克模型。用128只Wistar大鼠随机分成内毒素休克组(ESG),内毒素休克·人参二醇组皂甙预治疗组(ESPG),对照组(CG)。结果发现:ESPG组大鼠16h存活率高于ESG组(P<0.05),肺组织过氧化脂质含量则低于ESG组,两组差异显著(P<0.005);ESPG组大鼠8h、16h血清过氧化脂质含量低于ESG组(P<0.05),两组差异显著(P<0.05);血清和肺ESPG组去甲肾上腺素、5-HT含量低于ESG组。提示人参二醇组皂甙具有明显的抗休克作用。Experimental models were reproduced by injection of crude E. Coli. endotoxin into the abdominal cavity in rats. One handred and twenty-eight Wistr rats were -randomly divided into 3 groups: endotoxic shock ( ESG ) , group pretreated with psnasadiol saponin (ESPG) and control group(CG). It was found that 16h survival rate in ESPG was higher than that in ESG(P<0.05) and content of lipidper-oxide in lung was significantly lower in ESPG than in ESG ( P < 0.005); lipidperoxide in the serum in ESPG was significantly lower than in the ESG at 8h and 16h after injection (P<0.05); Noradre-naline and 5-HT in the serum and lung was lower than in ESG. It showed that panaxadiol saponin has a protective effects againsit endotoxic shock in rats

关 键 词：内毒素 休克 人参 过氧化脂质 

分 类 号：R285.5[医药卫生—中药学]