冬凌草甲素对麻醉开胸家兔血流动力学的作用  

EFFECTS OF ORIDONIN ON THE HEMODYNAMICS IN ANAESTHETIZED RABBITS

作　　者：李琦[1] 陈正[1] 刘洁[1] 孙汉董[2] 林中文[2] 

机构地区：[1]白求恩医科大学药理教研室,长春130021 [2]中科院昆明植物研究所,650204

出　　处：《中国药理学通报》1992年第1期53-55,共3页Chinese Pharmacological Bulletin

摘　　要：冬凌草甲素3.0mg,10.0mg/kg iv能使麻醉家兔心脏的LVSP,±dP/dt_(max),V_(pm),P-dP/dt,环体面积等均缩小,t-dP/dt_(max)延长,HR减慢,即负性肌力、负性频率作用。此外冬凌草甲素还具有明显的降压作用,其特点是DBP下降幅度大于SBP,推测冬凌草甲素可能具有抗扩张血管作用。Oridonin is ent-kaurane diterpenoid and is one of the efficacious component of Rabdosia Rubesecens ( Hemel. ) Hara in Henan province. In this experiment, the effects of Oridonin on hemody-namics of anaesthetized rabbits were studied. Hemodynamics effects of Oridonin (3.0 mg, 10.0mg/kg iv)were noticed. LVSP, ±dP/dt_max, Vpm, Lo, HR, SBP, DBF were decreased. t-dP/dt_max was increased. LVEDP did not changed. Oridonin decreased DBP more than SBP, it is suggested that Oridonin. may reduce vascular smooth muscle tone.

关 键 词：冬凌草甲素 血流动力学 

分 类 号：R285.5[医药卫生—中药学]