国产单硝酸异山梨醇酯对心肌梗塞大鼠血液动力学的影响  

EFFECTS OF NATIVE ISOSORBIDE MONONITRATE ON HEMODYNAMICS IN RATS WITH MYOCARDIAL INFRACTION

作　　者：陶亮[1] 金其泉[1] 

机构地区：[1]蚌埠医学院药理教研室,安徽233003

出　　处：《中国药理学通报》1992年第2期128-130,共3页Chinese Pharmacological Bulletin

摘　　要：本文研究了国产单硝酸异山梨醇酯(isosorbide mononi—trate ISMN)对结扎左冠状动脉造成的心肌梗塞大鼠血液动力学的影响。IS MN(5 mg/kg)能升高心肌梗塞后早期(20min)的左室收缩压峰值(LVSP),左室内压等容收缩期最大上升及下降速率(±dP/dt_(max));同时降低左室舒张末期压(LVEDP);但不影响HR、SAP、DAP和MAP。实验结果表明:国产ISMN能改善心肌梗塞后早期的心功能。Tho effects of native isosorbide mononitrate ( ISMN ) on the hemodynamics in rats with early myocardial infarction by left coronary artery occlusion were investigated. LVSP and dP/dtMAX were increased, and LVEDP was decreased with ISMN 5mg/kg i.v. 20 min after coronary occlusion. However, ISMN did not significantly effect the HR, SAP, DAP and MAP. The results showed that ISMN can improve cardial function in early myocardial infarction.

关 键 词：心功能 心肌梗塞 山梨醇酯 

分 类 号：R965.1[医药卫生—药理学]