人参茎叶总甙及Rb_1等单体对病毒感染细胞的保护作用  

Protection of ginsenoside on cultured cells from virus

作　　者：李静波[1] 张鸿源[1] 马兴元[2] 

机构地区：[1]白求恩医科大学地方病研究所,长春130021 [2]白求恩医科大学地方病研究所化学教研室,长春130021

出　　处：《中国药理学通报》1992年第3期221-224,共4页Chinese Pharmacological Bulletin

摘　　要：利用细胞培养技术观察人参茎叶皂甙(GNS)及Rb_1等单体对病毒感染细胞的保护作用。结果表明:GNS有明显的抑制HSV—I、HSV—Ⅱ、ADV—Ⅲ及VSV病毒在细胞内复制的作用,使细胞受到保护;其有效单体以Rb族为主。用含GNS霜剂对31例HSV—Ⅰ感染的口唇疱疹和口腔溃疡患者进行涂敷治疗,治愈27例(占87.10％)。本实验结果为临床应用GNS治疗某些病毒性疾病提供了一定的实验依据。The protection of ginseno-side (GNS ) isolated from leaves and stems on cultured cell from virus were observed. The results showed that GNS, especially the Rb1 monomer could suppress replication of virus such as HSV -Ⅰ , HSV-Ⅱ ,ADV- Ⅲ and VSV, and protect the cultured cells from virus infec- tion. A cream containing GNS was used in the treatment of herpes lebialis infected by HSV- I and 27 of 31 (87. 1%) cases were cured.

关 键 词：人参茎叶皂甙 病毒感染 

分 类 号：R285.5[医药卫生—中药学]