苄普地尔抗心律失常作用  

Antiarrhythmia effects of bepridll

作　　者：谷淑玲[1] 陈锦明[1] 崔家勇[1] 彭振云[2] 

机构地区：[1]徐州医学院药理教研室,江苏221002 [2]徐州医学院化学教研室,江苏221002

出　　处：《中国药理学通报》1992年第4期285-287,共3页Chinese Pharmacological Bulletin

摘　　要：苄普地尔iv能明显提高乌头碱诱发大鼠心律失常用量及豚鼠心脏哇巴因中毒耐量;对BaCI_2、Adr诱发的实验性心律失常有明显对抗作用;对大鼠冠脉结扎复灌注引起的心律失常有保护作用。Bepridil (10mg · kg-1) iv elevated the threshold dose of ouabain (15ug · min-1 iv) in guinea-pig and aconitine (10μg · kg-1 · min-1 iv) in rat induced ventricular extrasystole, ventricular tachycardia, ventricular fibrillation and cardiac arrest. It shortened the duration of arrhythmia elicitde by Adr (50ug · Kg-1 iv) in conscious rabbits and by BaCl2 (3mg · kg-1 iv) in rats. It is also effective in preventing reperfusion-induced arrhythmias in aneasthetized rats.

关 键 词：苄普地尔 心律失常 

分 类 号：R972.2[医药卫生—药品]