二氢埃托啡对吗啡依赖大鼠和猴的实验治疗  

Experimental therapeutic effects of dihydroetorphine in morphine-dependent rats and monkeys

作　　者：王丹心[1] 柳用绍[1] 秦伯益[1] 

机构地区：[1]军事医学科学院毒物药物研究所,北京100850

出　　处：《中国药理学与毒理学杂志》1992年第1期36-40,共5页Chinese Journal of Pharmacology and Toxicology

基　　金：国家医药管理局<八五>攻关专题№85-922-02-22

摘　　要：二氢埃托啡(DHE)能明显缓解吗啡依赖大鼠和猴用纳洛酮(Nal)催促或停用吗啡后出现的戒断症状,DHE对吗啡依赖猴替代治疗的疗效与美沙酮(Met)相当,经9d替代治疗,Met替代组动物Nal催促后仍出现一定的戒断症状,而DHE替代组动物未见戒断症状.Dihydroetorphine (DHE) successfully suppressed abstinence syndrome of morphine dependent rats and monkeys precipitated by naloxone or resulted from morphine withdrawal. The substitute therapeutic effect of DHE in morphine-dependent monkeys was the same as methadone. After 9 d of substitute therapies, methadone treated monkeys ap-peared abstinence syndrome after naloxone precipitation, whereas there were no abstinence syndrome in DHE group.

关 键 词：二氢埃托啡 吗啡依赖 戒断症状 

分 类 号：R996[医药卫生—毒理学]