人参三醇皂甙对人白细胞介素4基因表达的促进效应  

Effect of panaxatriol ginsenoside on gene expression of human interleukine-4

作　　者：田志刚[1] 杨贵贞[2] 

机构地区：[1]山东省医学科学院基础医学所,250001 [2]白求恩医科大学免疫学教研室

出　　处：《中国药学杂志》1992年第1期10-11,共2页Chinese Pharmaceutical Journal

摘　　要：应用mRNA麦胚无细胞体外转译体系,动态地观察了人参三醇皂甙(PTGS)对人淋巴结细胞白细胞介素4(IL-4)基因表达的促进效应。结果表明,PTGS 可以明显促进 PHA(植物血凝素)活化人淋巴细胞分泌 IL-4,最大促进效应可达63.33%。PTGS+PHA 共刺激后人淋巴细胞胞浆 IL-4mRNA 转译 IL-4的量明显高于单纯 PHA 组,最大促进效应达95%。从而首次证实 PTGS 促 IL-4分泌与 PTGS 促 IL-4 基因表达密切相关。Effect of panaxatriol ginsenoside(PTGS)oninterleukine-4(IL-4)induction of PHA-stimulatedhuman lymph node cells was observed.The resultsshowed that PTGS enhanced IL-4 production oneach time of IL-4 induction kinetics,maximally by 63. 33%(48h).Furthermore,IL-4 mRNA fromPHA+PTGS-stimulated lymph node cells trans-lated more IL-4 than PHA-stimulated lymph nodecells on each time of IL-4 mRNA-induction kinet-ics,maximally by 95%(30h),using the methodsof wheat germ cell-free in vitro translation systemand IL-4 bioassay.It is the first report on IL-4gene regulation by ginsenoside or any other kindof Chinese herbs.

关 键 词：白细胞介素 人参三醇皂甙 人参皂甙 

分 类 号：R282.710.5[医药卫生—中药学]