脂质体改善动脉粥样硬化机制探讨  

Phospholipid liposomes in antiatherosclerosis division of cardiology

作　　者：刘晓勤[1] 徐宁生[1] 孟庆玲[1] 赵春玉[1] 薛琳[1] 曾青[1] 赵蕊[2] 文宗曜[3] 胡大鹏 邹凯莉 

机构地区：[1]北京医科大学第一医院心血管研究室,100034 [2]北京医科大学第三医院病理科 [3]北京医科大学物理教研室 [4]黑龙江牡丹江温春制药厂研究室,157041

出　　处：《中国药学杂志》1992年第6期343-345,共3页Chinese Pharmaceutical Journal

摘　　要：向进食高脂兔耳静脉多次注射脂质体(人工生物膜 liposomes)使血清总胆固醇(TC)、甘油三酯(TG)下降,体内过多的磷脂(PL)排出增加,全血粘度和血浆粘度下降,改善红细胞硬度和变形性,使动脉粥样硬化(AS)显著减轻。After multiple intraveneous injection of lipo-somes prepared from phospholipids into diet-inducedatherosclerosis rabbits,the elevated serum choles-terol level and the excessive phospholipid were re-moved through the enhanced reverse cholesteroltransport mechanism.The reduced RBC deformabi-lity caused by hyperlipideamia increased and thebloods viscosity decreased.The substantial shringeof atherosclerosis deposits in the aorta was deter-mined.

关 键 词：脂质体 动脉粥样硬化 

分 类 号：R972.6[医药卫生—药品]