周络通对糖尿病周围神经病变大鼠坐骨神经功能影响  

Effect of Zhouluotong on rat's sciatic nerve function and polyol pathway with diabetic peripheral neuropathy

作　　者：封卫毅[1] 侯家玉[1] 陈伟[2] 王晶[1] 

机构地区：[1]北京中医药大学中药学院药理教研室,北京100102 [2]河北医科大学中医系

出　　处：《中成药》2004年第4期318-321,共4页Chinese Traditional Patent Medicine

摘　　要：目的 :研究周络通 (黄芪 ,桂枝 ,当归 ,生地 ,细辛等 )对链脲佐菌素 (STZ)糖尿病大鼠坐骨神经功能和多元醇代谢通路的影响。方法 :动物ig给药 ,连续 8周 ,观察药物对链脲佐菌素糖尿病大鼠坐骨神经形态学改变、神经传导速度、坐骨神经Na+,K+ ATP酶和醛糖还原酶活性及山梨醇、肌醇、果糖、葡萄糖、甘露糖等多元醇含量的影响。结果 :周络通对链脲佐菌素糖尿病大鼠坐骨神经形态学改变有明显保护作用 ,坐骨神经传导速度明显性提高 ,Na+,N+ ATP酶活性增强、醛糖还原酶活性降低 ,山梨醇、葡萄糖含量降低。结论 :周络通可改善糖尿病大鼠周围神经组织的代谢 ,改善神经组织功能 ,对STZ糖尿病大鼠周围神经病变具有防治作用。AIM:To investigate the effects of Zhouluotong (Radix Astragali, Ramulus Cinnamomi, Radix Angelicae Sinensis, Radix Rchmannia, Herba Asari, etc.) on nerve function and polyol pathway in streptozotocin diabetic rats. METHODS: Streptozotocin diabetic rats were administrated with Zhouluotong for 8 weeks. Effects of drugs on sciatic never morphological alterations, sciatic never conduction velocity, aldose reductase activity, Na +,K + ATPase activity and sciatic nerve polyol contents were determined. RESULTS: Compared with diabetic group, sciatic never morphological alterations was improved, sciatic never conduction velocity was increased, aldose reductase activity was depressed and Na +,K + ATPase activity was increased in each administrated group. Sorbitol and gloucose contents were decreased in Zhouluotong groups. CONCLUSION: Zhouluotong could improve metabolism and function of peripheral nerve issue in streptozotocin diabetic rats. As a result of that, it could prevent diabetic peripheral neuropathy in streptozotocin diabetic rats.

关 键 词：周络通 糖尿病周围神经病变 多元醇通路 醛糖还原酶 NA^+ K^+-ATP酶 

分 类 号：R285.5[医药卫生—中药学]