麋鹿角乙醇提取液抗衰老作用研究  

Studies on anti-ageing effect of elk antlers ethanolic fluidextracr

作　　者：秦红兵[1] 杨朝晔[1] 朱清[2] 朱毅芳[2] 

机构地区：[1]盐城卫生学校,江苏盐城224006 [2]南通医学院,江苏南通226001

出　　处：《中成药》2004年第4期322-324,共3页Chinese Traditional Patent Medicine

摘　　要：目的 :研究麋鹿角乙醇提取液的抗衰老作用。方法 :制备D 半乳糖亚急性衰老模型 ,观察麋鹿角乙醇提取液对小鼠衰老相关酶的影响 ;正常小鼠给予麋鹿角乙醇提取液 ,测定小鼠耐缺氧时间、游泳时间及免疫器官指数 ,观察其抗应激作用及对免疫功能的影响。结果 :麋鹿角乙醇提取液能提高衰老小鼠血中SOD活性 ,降低MDA含量 ,延长小鼠缺氧条件下的存活时间和游泳时间 ;提高小鼠脾指数 ,减少胸腺指数。结论 :麋鹿角乙醇提取液具有抗氧化作用 ;能增强小鼠耐缺氧和耐疲劳能力 ;对免疫功能有一定的调节作用。AIM: To study the anti ageing effect of elk antlers ethanolic fluidextract. METHODS: The subacute ageing model mice induced by D galactose was established and was given elk antlers ethanolic fluidextract for 30 days. SOD and MDA activity of the blood in the mice was determined at the end of experiment. The anti stress action and the immunomodulation were measured by determining the surviving time under hypoxic condition and swimming time and by determining the immune organ index, respectively. RESULTS: Elk antlers ethanolic fluidextract could raise SOD activity and reduce MDA content of the blood in subacute ageing model mice. It could prolong the surviving time under hypoxic conditon and swimming time in mice. It could also increase spleen index and reduce thymus index in mice. CONCLUSION: Elk antlers ethanolic fluidextract has anti oxidation action. It can strengthen the ability to bear hypoxic condition and tiredness in mice.It has certain action to regulate immune function.

关 键 词：麋鹿角 抗衰老 抗氧化 抗应激 免疫调节 小鼠 

分 类 号：R285.5[医药卫生—中药学]