复方益母草膏治疗痛经药理机制的实验研究  

Experimental researches of antidysmenorrhea actions of Compound Yimucao Paste

作　　者：李毅敏[1] 周连发[1] 王士贤[1] 

机构地区：[1]天津市医药科学研究所,天津300070

出　　处：《中成药》2004年第4期311-314,共4页Chinese Traditional Patent Medicine

摘　　要：目的 :研究复方益母草膏 (益母草、川芎、当归、红花 )治疗痛经的药理学作用机制。方法 :观察复方益母草膏对肾上腺素所致小鼠耳廓微循环障碍的影响 ,观察复方益母草膏对催产素所引起的离体大鼠子宫平滑肌收缩作用及小鼠扭体次数的影响。结果 :复方益母草膏可以明显扩张小鼠耳廓微动脉和微静脉的管径 ,加快血流的速度 ;对催产素引起的子宫平滑肌的收缩具有抑制作用 ;整体实验也证明对小鼠有减少扭体的次数 ,治疗痛经的作用。结论 :复方益母草膏具有明显的改善微循环 ,抑制催产素引起的子宫平滑肌收缩的作用 ,有助于缓解痛经。AIM: To investigate the antidysmsenorrhea pharmacologic effects of Compound Yimucao Paste (Herba Leonuri, Rhizoma chuanxiong, Radix Angelicae Sinensis, Flos Carthami) METHODS: The methods of microcirculation and isolated uterus smooth muscle of rat were used. RESULTS: Compound Yimucao Paste could improve the microcirculation disturbance on the aspects of the diameter, the velocity of mice auricle microarterioles and microveins, inhibit the isolated uterus smooth muscle contraction and mouse twister induced by oxytocin. CONCLUSION:Compound Yimucao Paste has an obvious action of blood quickening and stasis transforming and inhibit the isolate and uterus smooth muscle contraction induced by oxytocin, which are contributed to its antidysmenorrhea effect.

关 键 词：复方益母草膏 微循环 子宫收缩 痛经 

分 类 号：R285.5[医药卫生—中药学]