槲皮素磷酸酯钾对冠脉流量及心肌耗氧量的影响  

Effect of potassium quercetin phosphate(PQP)on coronary blood flow and myocardial oxygen consumption

作　　者：汤允昭[1] 陶然[1] 郝一彬[1] 王志平[1] 张萍[1] 梁克军 

机构地区：[1]山西医学院药理教研室,030001 [2]太原第二制药厂,030021

出　　处：《中国药学杂志》1992年第12期722-724,共3页Chinese Pharmaceutical Journal

摘　　要：iv 檞皮素磷酸酯钾(potassium quercetin phosphate,简称 PQP)20mg/kg 能增加猫的冠脉流量,对血压、心率及心肌耗氧量均无显著影响。小鼠 ipPQP 200mg/kg 能显著增加心肌营养性血流,但对小鼠心肌耐缺氧时间无明显影响。小鼠 ivPQP 的 LD_(50)为238.5±26.5mg/kg。The effects of potassium quercetin phosphate(PQP)on the coronary blood flow and myocardial oxygen consumption were studied in 8 anesthetizedopen-chest cats.The results showed that coronaryblood flow was markedly increased(P<0.05),but did not singificantly influence the heart rate,blood pressure and myocardial oxygen consump-tion after iv PQP 20 mg/kg.We also observed theeffects of PQP on the nutritional myocardial bloodflow by iv ^(99m)Tc-MIBI and the resistance of hy-poxia after SC isoprenaline in mice.Intravenousadministration of 200mg/kg PQP was able to in-crease markedly the nutritional myocardial bloodflow(P<0.01),but the resistance of hypoxia wasnot influenced.The results suggest that PQP is ofvalue as an antimyocardial ischemia agent.

关 键 词：槲皮素 冠脉流量 心肌耗氧量 

分 类 号：R972[医药卫生—药品]