益母草药材生物检定方法的研究(Ⅲ)——鲜益母草胶囊和益母草流浸膏生物效价与临床疗效的相关性观察  

Study on the biological assay of herba leonuri III——related observation of fresh Herba Leonuri capsules and Herba Leonuri fluid extracts in biological potency and clinical effect

作　　者：杨明华[1] 王溶溶[1] 

机构地区：[1]浙江省中药研究所,浙江杭州310023

出　　处：《中国现代应用药学》2004年第2期124-126,共3页Chinese Journal of Modern Applied Pharmacy

基　　金：浙江省自然科学基金资助 ( 3 985 13 )

摘　　要：目的　考察鲜益母草胶囊和益母草流浸膏的生物效价与临床疗效的相关性 ,验证建立的益母草生物检定方法的科学性。方法　在大鼠标准子宫模型上 ,运用已建立的益母草生物检定平行线四点法[1,2 ] ,对鲜益母草胶囊和益母草流浸膏进行效价测定 ;同时进行临床疗效观察 ,比较效价与疗效的相关性。结果　鲜益母草胶囊和益母草流浸膏 3次测定的平均效价分别为 (0 .0 5 2 7± 0 .0 0 31)u/g和 (0 .0 4 2 7± 0 .0 0 2 9)u/g(两者比较P <0 .0 5 )。 6 0例临床试验表明 ,鲜益母草胶囊和益母草流浸膏对妇女产后 7d子宫底高度单个症状积分值分别为 1.17± 0 .37和 1.5 0± 0 .6 2 (两者比较P <0 .0 5 )。结论　鲜益母草胶囊和益母草流浸膏的生物效价与临床疗效具有正相关。OBJECTIVE To observe the relationship between FHLC and HLFE in biological potency and clinical effect and test the accuracy of the biological assay of Herba Leonuri. METHOD In the light of establishing effective pattern. Survey the potency of FHLC and HLFE, do the observation of their clinical effect and compare the results.RESULTS The biological potency of FHLC and HLFE are (0.0527±0.0031)u/g and (0.0427±0.0029)u/g respectively. The difference was significal (P<0.05).Clinical trial showed that the effect of contracting uterus of FHLC is better than that of HLFE.CONCLUSION There is a positive relationship between biological potency and clinical effect on FHLC and HLFE.

关 键 词：鲜益母草胶囊 益母草流浸膏 生物效价 临床疗效 相关性 

分 类 号：R965.2[医药卫生—药理学] R284[医药卫生—药学]