脂质体作为皮肤局部给药载体的研究进展  

The progresses of liposomes as carrier for dermal topical administration

作　　者：吴宏霞[1] 蔡鸿生 罗顺德[1] 何文[1] 

机构地区：[1]武汉大学人民医院药剂部,湖北武汉430060

出　　处：《中国现代应用药学》2004年第2期115-118,共4页Chinese Journal of Modern Applied Pharmacy

基　　金：湖北省科技攻关计划项目编号 2 0 0 13 0 10 6AA3 0 1B0 6

摘　　要：目的　了解脂质体作为皮肤局部给药载体的研究进展。方法　以大量有代表性的文献进行分析、归纳 ,阐述了脂质体作为皮肤局部给药载体的特点、机制、处方设计、实验研究及新型脂质体的研究。结果　脂质体作为皮肤局部给药的载体具有许多优点 ,但作用机制不一 ,影响因素很多 ,新型脂质体的研究使脂质体皮肤给药的前景更为广阔。结论　外用脂质体制剂将有巨大的发展潜力。OBJECTIVE The recent progresses of liposomes as a carrier for dermal topical application were introduced. METHOD A lot of typical literatures were cited to analyse and summarize,and the characters,mechanism,formulation design,experimental studies and novel liposomal substitutes of liposomes as a carrier for dermal topical application were presented.RESULTS The liposomes have many virtues as a carrier for dermal topical application and have various machanisms and influence factors.The study of novel liposomes brings a broad prospect for dermal application.CONCLUSION External liposomal preparations will have a huge developmental potential.

关 键 词：脂质体 皮肤局部给药 药物载体 

分 类 号：R943.4[医药卫生—药剂学]