磷霉素钠注射液与2种维生素类药物配伍的稳定性考察  

Study on compatible stability of fosfomycin sodium with Vitamin B_6 and Vitamin C

作　　者：杨佩磊[1] 戚爱群[1] 夏晓萍[1] 

机构地区：[1]浙江大学医学院附属妇产科医院,浙江杭州310006

出　　处：《中国现代应用药学》2004年第2期157-159,共3页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的　考察室温下维生素C ,维生素B6分别与磷霉素钠注射液配伍稳定性。方法　采用紫外分光光度法测定 8h内各配伍液中各自的含量变化情况 ,并进行了外观观察 ,pH值测量。结果　室温条件下 ,磷霉素钠与VC配伍后其外观、pH值及含量都有变化 ,磷霉素钠与VB6配伍后其外观pH值及含量均无明显变化。结论　上述条件下磷霉素钠不宜与VC混合输注 ,磷霉素钠与VB6配伍稳定。OBJECTIVE To Study the compatible stability of fosfomycin sodium with Vitamin B 6 and Vitamin C under normal atmosphere temperature. METHOD Determination of fosfomycin sodium, Vitamin B 6 and Vitamin C in compatible solution, and observation of pH and appearance of compatible solution within 8h by ultraviolet spectrophotometry and pH meter.RESULTS Under the normal atmosphere temperature, the content of fosfomycin and Vitamin C varies in compatible solution, with pH and the appearance. On the contrary, the content of fosfomycin and Vitamin B 6 is steady in compatible solution, with approximate stability of pH and appearance.CONCLUSION It is not suitable for fosfomycin to mix with Vitamin C, but adaptable to Vitamin B 6 .

关 键 词：磷霉素钠 维生素C 维生素B6 配伍稳定性 

分 类 号：R978.1[医药卫生—药品] R969.2[医药卫生—药学]