铅对孕鼠甲状腺功能影响的形态学观察  

MORPHOLOIC OBSERVATION OF THE EFFECT OF LEAD ON THYROID GLAND OF PREGNANT RATS

作　　者：朴丰源[1] 万伯健[1] 朱文韬[1] 王明武[2] 张福会[2] 赵燕妮[2] 宋今丹[2] 

机构地区：[1]中国医科大学预防医学系卫生毒理学教研室 [2]中国医科大学基础医学部电镜中心实验室

出　　处：《中国医科大学学报》1992年第2期120-122,共3页Journal of China Medical University

摘　　要：作者用醋酸铅作为受试物,以三组剂量(20mg/kg、40mg/kg、60mg/kg)于大鼠受孕第13、16、19天3次腹腔注射染毒,对照组给生理盐水。结果:光镜下甲状腺组织呈明显的低功改变,并有退行性变趋势。电镜下滤泡上皮细胞呈萎缩性改变,有关蛋白质代谢的细胞器不发达,分泌颗粒、溶酶体及胶质小泡的数量也明显减少。提示醋酸铅对甲状腺有明显的毒性作用。Pregnant rats were given different dosages of acetate lead (20, 40 and 60 mg/kg) introperitoneally at the 13th, 16th, 19th day of prenancy.Normal saline was given as control.The pathologie changes of thyroid gland caused by lead were observed. With light micrcscope, hypofunctional changes were seen and the tissue showed tendency of retrograde degeneration.Follicular epithelial cells exhibited atrophic appearance in electrono microscope, and the cell organelles in relation to protein metabolism could poorly be seen.The quantities of secretory granules, lyscsomes and colloid-containing vesicles were also found reduced greatly.It suggests that acetate lead has obviously toxic effect on thyroid gland.

关 键 词：醋酸铅 甲状腺 电子显微镜 

分 类 号：R994.1[医药卫生—毒理学]