氢过氧化亚油酸对家兔动脉内皮细胞的损伤作用  

INJURIOUS EFFECT OF LINOLEIC ACID HYKROEROXIDE ON ARTERIAL ENDOTHELIAL CELLS OF RABBITS

作　　者：董玉兰[1] 陈铁镇[1] 王殿鸿[2] 马朗[2] 王佐周[1] 张亚佳[1] 王铁吉[1] 王跃忠[1] 

机构地区：[1]中国医科大学基础医学部实验病理学研究室 [2]中国医科大学生物化学教研室

出　　处：《中国医科大学学报》1992年第6期401-404,共4页Journal of China Medical University

基　　金：国家"七五"科技攻关课题

摘　　要：用不同浓度氢过氧化亚油酸(LAH)作用于家兔隔离颈动脉段3～5min,于不同时间处死动物。在光镜、电镜下观察过氧化脂质引起的动脉内皮细胞(EC)损伤。结果主要表现为EC的收缩,通透性升高和以质膜泡形成为特点的生物膜系统损伤,以及单核细胞(MC),平滑肌细胞(SMC)的反应。Linoleic acid hydroperoxide with different concentrations was infected for 3～5 minntes into a defined segment of carotid artery of rabbits9 which were lilled at 3, 24, 48 houts and 49 7 days after the infection. Damage of arterial cndothelial cells induced by lipid peroxide was observed ty light, scanning and transmission electren microscopy. The main damagel is the contraction of endothelial cells, increase of permeability, biomembrane system injury characterized by plasma membrane blebbing and reaction of monceytes and smooth muscle cells.

关 键 词：动脉粥样硬化 过氧化脂质 内皮细胞 

分 类 号：R541.4[医药卫生—心血管疾病]