免疫抑制在布鲁氏菌病发病机理中的作用  

A study on the Role of Immunosuppression in the Pathogenesis of Brucellosis

作　　者：张见麟[1] 郭宝岚[1] 崔春槐[1] 吕秀芝[1] 王惠秋[1] 陈贤辉[1] 唐浏英[1] 

机构地区：[1]中国预防医学科学院流行病学微生物学研究所

出　　处：《中国医学科学院学报》1992年第3期168-172,共5页Acta Academiae Medicinae Sinicae

基　　金：自然科学基金

摘　　要：以纯系小鼠为模型,细胞免疫学方法表明布鲁氏菌病(布病)具有免疫抑制作用,且此抑制作用可被左旋咪唑、白细胞介素-2,猪苓多糖及Bestatin等免疫调节剂缓解,提示免疫抑制作用参与布病的发病过程,为改进布病临床治疗方案,筛选治疗慢性布病药物的动物模型及客观疗效指标提供了依据。An immunosuppressive effect was seen in murine brucellosis as detected by using plaque forming cell (PFC) and 3H-labelled lymphocyte blastogenesis transformation (LBT) assays. The immunosuppression PFC could last until 11 months after infection, while that of LBT was only seen at 3 months after infection. This immunosuppression could be relieved by using immunomodulators such as levamisole, bestatin, IL-2 and polyporus umbellatus. IL-2 and poly-porus umbellatus could reverse the suppression to normal levels. Thus, this study provided evidence that immunosuppression is a component of pathogenessis of brucellosis.

关 键 词：布鲁氏菌病 免疫抑制 白细胞介素 

分 类 号：R516.703[医药卫生—内科学]