膜糖蛋白PC-1基因K121Q多态性与2型糖尿病相关性  

Association of membrane glycoprotein PC-1 gene K121 Q polymorphism with type 2 diabetes

作　　者：徐梅[1] 王德全[1] 许玲[1] 唐宽晓[1] 司元国 

机构地区：[1]山东大学齐鲁医院内分泌科 [2]青岛市糖尿病内分泌研究所

出　　处：《中华内分泌代谢杂志》2003年第5期390-391,共2页Chinese Journal of Endocrinology and Metabolism

摘　　要：运用PCR RFLP方法分析膜糖蛋白PC 1基因K 12 1Q多态性 ,观察Q、K等位基因和KQ、KK基因型在正常对照组和 2型糖尿病组中的分布 ,同时测定多种生化及临床指标。结果显示 ,Q等位基因与 2型糖尿病有相关性 ,且与 2型糖尿病伴肥胖、高血压。K121Q polymorphism of membrane gl yc oprotein PC-1 gene was assayed by PCR-RFLP and distributions of Q, K alleles a nd KQ, KK genotypes were observed in 92 normal controls and 107 type 2 diabetic patients. The results suggest that Q allele is related to type 2 diabetes and ty pe 2 diabetes with obesity, hypertension and hyperlipidemia.

关 键 词：膜糖蛋白 PC-1基因 K121Q多态性 2型糖尿病 

分 类 号：R587.1[医药卫生—内分泌]