西咪替丁漂浮片和普通片在人体的相对生物利用度比较  

COMPARISON OF BIOAVAILABILITY OF CIMETIDINE HYDRODYNAMICALLY BALANCED SYSTEM AND NORMAL TABLET IN HUMAN-BODY

作　　者：肖大卫[1] 李景苏[1] 谢晓婵[1] 侯艳宁[1] 袁舒[2] 

机构地区：[1]白求恩国际和平医院临床药学室,石家庄050082 [2]红安县人民医院药剂科

出　　处：《中国医药工业杂志》1992年第1期16-18,共3页Chinese Journal of Pharmaceuticals

摘　　要：用HPLC法测定了西咪替丁漂浮片在健康受试者体内的血药浓度,比较了漂浮片即普通片在人体的相对生物利用度,经统计学处理,两者 AUC 无显著差异,F_R 为1.058±0.331。Cmax、tmax、k_a 均有显著差异(p<0.01),漂浮片在人体有明显缓释作用。The concentration in blood of cimetidine hydrodynamicallybalanced system was determined in six healthy volunteers with HPLC,and itsbioavailability was compared with the normal tablet.The statistical resultsshowed that their AUCs had no significant difference.The relative bioavailability(F_R)was 1.058.Their C_(max),t_(max) and k_a were all significantly different(p<0.01).The system had an obvious delay release action.

关 键 词：西咪替丁 漂浮片 HPLC 生物利用度 

分 类 号：R975[医药卫生—药品]