2,4-二氯氟苯的合成  

Synthesis of 2,4-dichloro fluorobenzene

作　　者：张继昌[1] 石蔚云[1] 王国喜[1] 

机构地区：[1]安阳大学化工系,河南安阳455000

出　　处：《应用科技》2004年第4期67-68,共2页Applied Science and Technology

摘　　要：2,4-二氯氟苯是合成喹诺酮类抗生素的重要中间体,随着环丙氟哌酸的广泛应用,国内外2,4-二氯氟苯需求急剧增加.在此概述了由2,4-二氯苯胺经过重氮化、置换制得2,4-二氯氟苯的生产新工艺,产品纯度达到99.2%,收率50.2%.新工艺具有安全可靠,原材料易得,成本较低,产品纯度高等优点,比较适宜于工业化生产.2,4-Dichlorofluorobenzene is an organic intermediate for synthesizing ciprofloxacin,a broadspectrum antibiotics.With increasing consumption of ciprofloxacin,the demand for 2,4-Dichlorofluorobenzene is increasing at home and abroad.2,4-Dichlorofluorobenzene is prepared by diazotizating of 2,4-dichloro aniline and substituting of 2,4-dichloro diazo benzene with fluorinion.The purity is 99.2% and the yield is (50.2%.)This new process is simple and suitable for industrial production.

关 键 词：2 4—二氯氟苯 合成工艺 喹诺酮类抗生素 中间体 

分 类 号：TQ465[化学工程—制药化工]