甘草制剂——甘酮酸抗溃疡作用研究  

STUDIES ON ACTION AGAINST PEPTIC ULCER OF GANTONGSAN

作　　者：戴静芝[1] 张君玮[1] 李可[1] 胡士亮 卢艳萍[1] 

机构地区：[1]上海医药工业研究院,上海200437

出　　处：《中国医药工业杂志》1992年第11期509-511,共3页Chinese Journal of Pharmaceuticals

摘　　要：甘酮酸100或200mg/kg ip一次,对 Shay 氏法幽门结扎大鼠能抑制溃疡形成,减少胃液的分秘;对阿司匹林诱发的大鼠出血性溃疡有抑制作用。甘酮酸100或200mg/kg po 10次,能抑制醋酸诱发的大鼠慢性溃疡,其抗溃疡作用与日本已上市的 FM100(Aspalon)相似。Gantongsuan,a fraction of licorice root,when 100～200mg/kggiven intraperitoneally,showed protective effect on ulceration and inhibition ofgastric secretion in pylorus ligated rats(Shay rats).It inhibited gastric ulcerinduced by aspirin.Oral administration of 100,200mg/kg×10 caused a potentinhibition of the acetic acid induced chronic gastric ulcer in rats.Its effectsagainst peptic ulcer were comparable to FM100(Aspalon).

关 键 词：甘酮酸 溃疡 病用药 

分 类 号：R965[医药卫生—药理学]