奋乃静的二阶导数高速脉冲极谱测定法  

QUANTITATIVE DETERMINATION OF PERPHENAZINE BY SECONDARY DERIVATIVE HIGH-SPEED PULSE POLAROGRAPHY

作　　者：梁云爱 张天民[2] 傅焰 

机构地区：[1]莒县药品检验所,山东276500 [2]山东医科大学,济南250012 [3]潍坊市药品检验所,山东261041

出　　处：《中国医药工业杂志》1992年第12期551-553,共3页Chinese Journal of Pharmaceuticals

基　　金：国家自然科学基金资助课题

摘　　要：运用二阶导数高速脉冲极谱法对奋乃静及其制剂进行定量测定。在含氢氧化钠-磷酸二氢钾的乙醇和水的底液中,于0.10V(vs Ag/AgCl)处出现良好的导数峰,于1.4×10^(-4)～7.4×10^(-4)mol/L 范围内,导数峰幅值与药物浓度呈线性关系。检测限为7.4×10^(-9)mol/L。方法简便、快速、灵敏,结果准确。The secondary derivative high-speed pulse polarography was de-veloped for the determination of perphenazine and its preparation.By usingethanol-water solution containing sodium hydroxide and potassium dihydrogenphosphate,there was very good derivative peak at 0.10V(vs Ag/AgCl).The line-ar relationship between concentration and peak height was obtained in the conc-entration range of 1.4×10^(-4)～7.4×10^(-4)mol/L.The determination limit was7.4×10^(-9)mol/L.This method is simple,rapid,sensitive and accurate.

关 键 词：脉冲极谱法 定量分析 羟哌氯丙嗪 

分 类 号：R927[医药卫生—药学]