头孢唑啉钠在腹膜透析液中的稳定性  

Stability of cefazolin sodium in peritoneal dialysate

作　　者：杨晓萍 许作强 张正霞 

机构地区：[1]徐州市第一医院药剂实验室,221002 [2]江苏省医科职工大专

出　　处：《中国医院药学杂志》1992年第6期263-264,共2页Chinese Journal of Hospital Pharmacy

摘　　要：本文观察头孢唑啉钠在25℃与37℃条件下与腹膜透析液配伍的稳定性。6袋500ml腹膜透析液(醋酸盐)各加入250mg头孢唑啉钠,3袋置37℃贮存,另3袋置25℃贮存、分别在0、2、4、8、12、24、48、72h取样,用紫外分光光度法测定含量。同时按中国药典85年版微粒检查项下,观察微粒情况,并测定pH值。结果在37℃贮存24h含量下降5%,25℃放置72h,含量几乎无变化。在整个观察期间,溶液澄明,显微镜下观察均未见沉淀产生。pH值变化很小(5.9±0.4)。The stability of cefazolin sodium in peritoneal dialysis solution (0.5mg/L) under two different temperature conditions (roomtemperature 25℃ and body temperature 37℃) was investigated over 72 hours period using UV-Spetrophtometry. The pH ofeach sample was determined, and the particals were observed by microscope. At 37℃ the initial mean cefazolin concentration de-clined to 95.0% at 24 hours, 89.1% and 86.1% at 48 and 72 hours, respectively; when stored at 25℃ for 72 hours, the initialcefazolin concentration had almost no change. The pH of all the dialysis solution was 5.9±0.4 throughout the study under allconditions, and no precipitate was observed by microscope.

关 键 词：头孢唑啉钠 腹膜透析液 稳定性 

分 类 号：R927.11[医药卫生—药学]