胰高血糖素抗大鼠失血性休克的研究  

ANTI-SHOCK EFFECT OF GLUCAGON ON HEMORRHAGIC SHOCK IN RATS

作　　者：刘少金[1] 席正雄[1] 张桂林[1] 

机构地区：[1]湖北医学院生理学教研室,武汉430077

出　　处：《中国应用生理学杂志》1992年第3期228-231,共4页Chinese Journal of Applied Physiology

摘　　要：在重度失血性休克大鼠上(MAP=3.33～3.87kPa)观察到,静脉注射胰高血糖素(20μg/kg)不仅使动脉血压回升,心率加快;而且还明显增加残余循环血量。用注射高渗葡萄糖的方法模拟胰高血糖素所致的高血糖浓度,提示胰高血糖素的升压作用与其升糖作用没有明显的关系。实验结果表明,胰高血糖素对急性失血性休克大鼠有良好的抗休克作用,其升压效应可能是通过增加心输出量和循环血量实现的。Glucagon (20μg / kg i.v.) induced not only increase in mean arterial blood pressure (from 3.6 to 11.6 kPa) and heart rate (from 216 to 353 beats/min), but also significant increase in volume of residual circulating blood (from 1.02 to 1.84 ml/100g) in the rats with severe hemorrhagic shock. Although glucagon also significantly increased the blood glucose concentration (from 123 to 161 mg%), injection of glucose (50%, 0.2ml / 100g iv.) did not show obvious effect on the arterial blood pressure at high blood glucose concentration (166 mg%). The results suggest that the anti-shock effect of glucagon may be due to increase in cardiac output and volume of circulating blood.

关 键 词：失血性 休克 胰高血糖素 动脉血压 

分 类 号：R605.971.4[医药卫生—急诊医学]