肾移植术后早期环孢菌素A引起的肝损害(英文)  

Cyclosporine induced liver damage in early stage after kidney transplantation

作　　者：邓宏[1] 刘建平[1] 王凤华[1] 唐化勇[1] 刘民媛[1] 

机构地区：[1]第四军医大学吉林军医学院附属医院泌尿外科,吉林132013

出　　处：《中国现代医学杂志》2004年第6期12-14,18,共4页China Journal of Modern Medicine

摘　　要：目的　探讨肾移植术后 3个月CsA免疫抑制剂的肝损害治疗措施。方法　对 19例出现肝功能异常的病例进行分析 ,测定肝功能异常时CsA的谷值浓度。及时调节免疫抑制剂用量 ,配合保肝利胆治疗。结果　 17例于 2～ 4周肝功能恢复正常。 2例无效 ,将CsA改为FK5 0 6后 1个月后 ,肝功能指标逐渐恢复正常。结论　低剂量CsA、MMF、pred三联是目前理想的免疫抑制治疗方案 ,结合保肝治疗 ,对减少术后早期CsA肝毒性的发生有一定疗效。Objective: To investigate the liver damage in early postoperative period and the measures for prevention and treatment. Methods:19 patients having abnormal liver function after kidney transplantation were analyzed. ALT or/and BIL were increased in all the patients. The triple-combined immunosuppression was adjusted. Active therapy was co-administered to decrease liver injury and protect liver function as well.Results: Liver function of 17 cases recovered. In the 2 cases with administering of Fk506 when CsA was stopped, ALT and BIL recovered after treatment for 1 month. Conclusions: With active therapy to decrease liver injury and protect liver function, the triple-combined immunosuppressive protocol(low dosage of CsA ?MMF and pred) is an ideal regimen of immunosuppressive therapy.

关 键 词：肾移植 肝疾病 

分 类 号：R699[医药卫生—泌尿科学]